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The native data set and the PtCl 4 derivative were collected at the DESY synchrotron in Hamburg, the remaining data sets were collected using CuKα radiation from a rotating anode source (Table ​ (TableI). However, only TRH-R1 is expressed at functional levels in the anterior pituitary. The TRH-mediated release of TSH is pulsatile with peak secretion being exerted between midnight and 4am, esteroides anabólicos hipogonadismo. Clinically, a phase II clinical trial using the AR antagonist bicalutamide to treat ERα/progesterone-receptor–negative tumors demonstrates a 19% clinical benefit rate (progression-free survival) over 6 months ( 118 ). A second phase II clinical trial using the more potent anti-AR drug enzalutamide in AR + , triple-negative tumors demonstrates a similar 25% clinical benefit rate at 16 weeks ( 119 ), esteroides anabólicos no androgénicos. She was taking no medication, esteroides anabólicos efectos físicos. 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